A hormonal change which naturally takes place in the human body at certain stages of life creates this skin problem called Acne. And it happens generally during the transition of a person from childhood to puberty and then on to teen age. In the elderly, it is triggered by the move in the middle age when the human body moves toward the post-menopausal stage.
The Four Pathogenic Factors Involved in AcneAn increase in the levels of androgens before and during adolescence leads to the production of greater amounts of sebum.The bacterium Propionibacterium acnes, which is resident on the skin of even healthy individuals, thrives on sebum. Increased sebum production in acne patients results in a proliferation of this micro-organism.Something goes awry in the infundibulum of the follicle in acne patients that causes cells from the follicle wall to clump together. This abnormal keratinization results in the clogged pores, or microcomedones, that can later proceed to other acne lesions.The presence of P acnes triggers the release of chemotactic factors that cause inflammation, as manifested by papules, pustules, and nodules.
Enhanced Quality of LifePatients who have acne often report an increase in their quality of life once their skin clears.The difference in quality of life is most dramatic in patients with severe disease who use systemic retinoids, but patients who use topical retinoids also are happy about the improvement in their skin.Proper use of retinoid is a rewarding part of dermatologic practice.
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